The prominent advantages of column chromatography silica gel in its application in biology engineering technology
 （1）with rigid skeleton structure, high mechanical strength，can stand the pressure within 30MPa；
  （2）excellent adsorption performance; It has ideal separation function to similar character and structure, even to isomer.
  （3）it has good thermal stability and chemical stability；
  （4）compared with organic column padding, silica gel is a solid, colloidal gel based on SiO2 matrix，its structure is compact, which will not pollute target product because there is no organic matter that can flow in process of application；
  （5）It can have selective adsorption and purification of the components of isomer from multi-component solution；
  （6）in preparation of column chromatography silica gel, a series of products with average pore diameter 20Å-20000Å can be produced through the control of different process conditions in order to adapt to the separation & purification of the substances with different character, molecular weight and molecular structure.